Congenital Insensitivity to Pain with Anhidrosis: a Miracle or a Curse?

Have you invariably wondered what life would be handle without physical disorder? Would life be more peaceful? Would we be more aggressive or would we perchance be incapable of enjoying the pleasures of life? We may think we atomic number 18 burst off without pain alone Pain is simply our intrinsic medical exam adviser to warn us and stimulate us (H. G. Wells, The Island of Dr. Moreau). Some commonwealth reserve been able to experience this anomaly, the ability to be incapable of experiencing whatsoever physical pain. These people are proven examples that pain is in particular necessary. Without pain one an never truly discover their bodys physical limits and may against their knowledge inflict a great portion of pain upon themselves. People with the unfitness to feel pain have the illness c wholeed innate Insensitivity to Pain with Anhidrosis (CIPA). CIPA is categorized as a Hereditary Sensory and Autonomic Neuropathic disease. Congenital Insensitivity to pain is the inability to feel uneasy sensations pertaining to an individual from birth. Anhidrosis is the inability to sweat so causing the incapability to mold body temperature. HSAN persona IV is a factortic disorder caused by multiple DNA mutations.These mutations exit on the neuropathic tyrosine kinase receptor types one (ntrk1 gene). In normal people the NGR (neuropathic gene receptor) stimulates the harvest support and the survival of the autonomic sympathetic neurons as well as nociceptive sensory neurons, which transmit pain sensations to the spinal cord and the brain. Mutations occur in portions of the gene that encode the intracellular and extracellular domain of the protein, which may affect the variability in presentation. Hereditary Sensory and Autonomic Neuropathic (HSAN) type IV causes CongenitalInsensitivity to Pain with Anhidrosis. HSAN IV is the second well-nigh common type of HSAN. CIPA symptoms normally manifest at an early age, but can be rugged to diagnose. Infant s with CIPA rarely cry from normal ailments, such(prenominal) as not crying when hungry as they cannot sentience hunger and they can sleep soundly throughout the night as they cannot sense their needs that need to be met. Parents believe it to be a goodwill that their child doesnt cry until other onset symptoms occur. These symptoms include unexplained fevers, self-mutilation, and developmental delay.When teething children often chew on anything they can, but since children with CIPA wear thint acquire the pain of biting themselves, teething becomes dangerous. more CIPA children embark on to bite off their own tongue and fingers when teething often rupture out their own teeth as well. Around this time, parents begin to realise that these symptoms are not normal for children. People with CIPA cant stay a normal life because of the many unfortunate ailments caused by the disease. Hyperactivity is a common characteristic of children with CIPA, as is eing unable to differentiat e between temperatures. Many children die early because it is very easy for them to overheat as they cannot thwart their own body temperature. The lack of sweating causes the skin to become compact and susceptible to skin infections and cellulitis. Their bones deteriorate over a shorter full stop of time than normal bones. Their joints are overused usually confining patients to a wheelchair (wheelchair bound). An outer space number of patients develop appendicitis and die because they are unable to feel the pain that this would normally cause.It is impossible to determine the number of CIPA patients, as thither is instead a discrepancy in the statistics. Unfortunately, there is no cure for CIPA, and they are very few treatment options. Since it is a rare disorder there hasnt been a lot of research done on the topic. To regulate the body temperature, some individuals with CIPA have to wear a special cooling system vest designed by NASA, and must have a controlled ther close toat . These individuals, like 11 year old Kayla Woodhouse, need to have a tank car filled with ice pack re-fills for her vest, and fluids to keep her hydrated.Other patients with CIPA wear gawk to protect their cornea, which would otherwise become damaged from their habit to scratch themselves. expansive Gingras is one of the well known CIPA patients who wears goggles to prevent further damage. loquacious also had to have her teeth removed by the age of both to prevent further irreparable damage to her fingers. People with CIPA need incessant supervision to avoid future injuries. Life without pain is more difficult than at first glance it wouldnt be as extraordinary as we would assume. Upon further investigation of CIPA, although it may seem like a wonderful thing t is an extremely dangerous disorder that most often results in premature death. Until we find a cure, people who have CIPA are forced to painlessly suffer. Imagine if humans could suddenly no longer feel physical pain Pharmaceutical companies, doctors, and manufacturing companies would cry all the way to their banks. Bibliography Axelrod, F. B. , von Simson, G. G. , Oddoux, C. (2008, August 5). Hereditary Sensory and Autonomic Neuropathy IV. GeneReviews. Retrieved November 15, 2008, from, http//www. ncbi. nlm. nih. gov/bookshelf/br. fcgi? book=gene&part=hsan4.Brown, A. (2006, May 20). Its not so easy universe a superhero. The Gazette. Retrieved December 1, 2008, from http//findarticles. com/p/articles/mi_qn4191/is_20060520/ai_n16434313. Lambert, K. (n. d). How CIPA Works. How Stuff Works. Retrieved November 12, 2008, from http//health. howstuffworks. com/cipa. htm/printable. Lee, B. (2008, November 17). Health Talk Congenital insensitivity to pain. The Tartan. Retrieved December 2, 2008, from http//www. thetartan. org/2008/11/17/scitech/healthtalk. Wells, H. G. (1988). The Island of Dr. Moreau. New York Signet Classic.